Impaired clearance of ceftizoxime and cefotaxime after orthotopic liver transplantation

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Impaired clearance of ceftizoxime and cefotaxime after orthotopic liver transplantation.

The pharmacokinetics of ceftizoxime (CZX) and of cefotaxime (CTX) were studied in five children and five adults after orthotopic liver transplantation (OLT). Delayed clearance of CZX (clearance of 0.21 to 1.26 ml/min per kg [body weight]) and CTX (clearance of 0.40 to 1.49 ml/min per kg) occurred in 7 of the 10 OLT patients. We conclude that abnormal CZX and CTX clearance is common after OLT an...

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Seizures after orthotopic liver transplantation

Orthotopic liver transplantation is the accepted treatment for endstage liver disease. In the US alone, more than 3000 patients receive liver transplants yearly distributed through more than 100 liver transplant programmes. Neurological complications occur in up to 47% of these patients. Among them, seizures are one of the most common. They tend to occur during the first few weeks after transpl...

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Complications After Orthotopic Liver Transplantation

Background Data Technical complications after OL Tx have a significant Impact on patient and graft survival. One of the principle technical advances has been the standardization of techniques for biliary reconstruction. Nonetheless. biliary complications stili occur. A 1983 report from the University of Pittsburgh reported biliary complications in 19% of all transplants, and an update in 1987 r...

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Histoplasmosis hepatitis after orthotopic liver transplantation

Histoplasmosis is an endemic mycosis in the Ohio and Mississippi River valleys and can cause disseminated infection in immunocompromised hosts. Disseminated histoplasmosis is often respiratory in nature and most cases in transplant patients occur within 2 years post-transplantation. A 32-year-old male on mycophenolate and tacrolimus who underwent an orthotopic liver transplantation 10 years pri...

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[Bacterial infection after orthotopic liver transplantation].

INTRODUCTION The authors reviewed the prevalence of postoperative infections, the results of bacterium cultures, and the incidence of multidrug resistance in their liver transplanted patients during a period between 2003 and 2012. AIM The aim of this study was to analyse risk factors and colonisations of bacterial infections. METHOD The files of 408 patients (281 bacterium cultures) were re...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1987

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.31.2.323